Coffee And Health: Liver Health. Numerous illnesses may have an influence on the health of the liver. This includes liver cancer and cirrhosis, a gradual illness characterized by hepatic steatosis (fatty liver) and excessive alcohol intake in which healthy tissue is replaced by scar tissue, impairing the liver’s function (Saab et al., 2014).
According to a recent meta-analysis of 16 human studies, coffee use decreases the risk of liver cancer by 40% when compared to no coffee consumption (Larsson and Wolk, 2007; Bravi et al., 2013).
Several in vitro studies have demonstrated that chlorogenic acids in coffee protect the liver from various types of damage, possibly by preventing cell apoptosis and oxidative stress damage through the activation of endogenous antioxidant and antiinflammatory body mechanisms, according to the researchers (Ji et al., 2013).
It has also been shown that coffee melanoidins may prevent the development of hepatic steatosis in obese rats (Vitaglione et al., 2012). This suggests that the melanoidins found in coffee may have an effect on the fat and function of the liver.
Despite the fact that melanoidins have not been found to be absorbed by humans, they may act as an antioxidant dietary fiber in the colon, neutralizing free radicals and maintaining the reduced/oxidized glutathione balance. Meanwhile, it may act as a prebiotic, influencing the microbiota of the colon and so enhancing the function of inflammatory pathways in the colon and, as a consequence, the liver.